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Cells Across the Body Communicate About Aging

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As we age, our bodies undergo numerous changes that can affect our overall health and well-being. Recent research has shown that these changes are not isolated to specific organs or systems but are instead influenced by communication between cells throughout the body. This intricate network of communication, known as intercellular signaling, plays a crucial role in regulating the aging process. By understanding how cells across the body talk to each other about aging, we can gain insights into potential interventions that may slow down or mitigate the effects of aging.

Cells Across the Body Communicate About Aging

The Importance of Intercellular Communication in Aging

Intercellular communication is essential for maintaining the proper functioning of our organs and systems. It allows different cells to coordinate their activities and respond to changing conditions. However, as we age, the lines of communication between cells can become compromised, leading to a breakdown in cellular communication and the onset of age-related diseases.

A study conducted by researchers at Washington University School of Medicine identified a critical communication pathway between the brain and the body’s fat tissue that appears to be central to energy production throughout the body. This feedback loop, which involves specific neurons in the brain’s hypothalamus, plays a crucial role in regulating the aging process. When these neurons are activated, they send signals to the body’s fat tissue to release energy. Maintaining the integrity of this communication pathway is key to healthy aging.

The Brain-Fat Tissue Feedback Loop

The feedback loop between the brain and fat tissue involves the production of specific proteins and the activation of the sympathetic nervous system, which governs the body’s fight or flight response. In the brain’s dorsomedial hypothalamus, a specific set of neurons produces an essential protein called Ppp1r17. When this protein is present, the neurons are active and stimulate the sympathetic nervous system, triggering a series of events.

First, the activation of the sympathetic nervous system sets off a chain reaction that stimulates neurons governing white adipose tissue, a type of fat tissue stored under the skin and in the abdominal area. These activated fat tissues release fatty acids into the bloodstream, providing a source of cellular fuel for physical activity. Additionally, the activated fat tissue releases an enzyme called eNAMPT, which returns to the hypothalamus and enables the brain to produce its own fuel.

Deterioration of the Brain-Fat Tissue Feedback Loop with Aging

Unfortunately, as we age, the brain-fat tissue feedback loop gradually deteriorates. The protein Ppp1r17 tends to leave the nucleus of the neurons in the hypothalamus, weakening the signals sent by these neurons. As a result, the wiring of the nervous system throughout the white adipose tissue retracts, leading to a decrease in the number of signals for releasing fatty acids and eNAMPT. This decline in communication contributes to fat accumulation, weight gain, and a decrease in energy available for the brain and other tissues.

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Manipulating the Brain-Fat Tissue Feedback Loop

The researchers at Washington University School of Medicine conducted experiments in mice to investigate the impact of manipulating the brain-fat tissue feedback loop on the aging process. By genetically modifying mice to maintain the presence of Ppp1r17 in the nucleus of the neurons in the hypothalamus or directly activating these specific neurons, they observed remarkable anti-aging effects.

Mice with a constant presence of Ppp1r17 in the neurons were more physically active, showed signs of delayed aging, and lived longer than control mice. On average, the mice in the experimental group lived 60 to 70 days longer than the control mice, representing a 7% increase in lifespan. These mice also exhibited a more youthful appearance, with thicker and shinier coats, indicating improved overall health.

Implications for Future Interventions

The findings from this study have significant implications for the development of future interventions that could slow down the effects of aging. By maintaining the integrity of the brain-fat tissue feedback loop, it may be possible to extend healthy lifespan and improve overall well-being.

The researchers are currently exploring different approaches to maintain this feedback loop. One avenue of investigation involves supplementing mice with eNAMPT, the enzyme produced by the fat tissue that fuels the hypothalamus and other tissues. This approach has shown promising results in increasing cellular energy levels in the hypothalamus and extending lifespan in mice.

Additionally, further research is needed to understand the complex interplay between intercellular communication, mitochondrial function, and aging. Mitochondria, often referred to as the powerhouse of the cell, play a crucial role in energy production and have been implicated in the aging process. Understanding how mitochondrial function is influenced by intercellular communication may provide additional insights into potential interventions for healthy aging.


Cells across the body communicate with each other about aging through intricate signaling pathways. The brain-fat tissue feedback loop, in particular, plays a crucial role in regulating energy production and overall health. Maintaining the integrity of this feedback loop is key to healthy aging.

The findings from recent studies offer exciting possibilities for future interventions that could slow down the effects of aging. By understanding the mechanisms of intercellular communication and their impact on mitochondrial function, researchers can develop targeted strategies to promote healthy aging and extend lifespan.

As our understanding of intercellular communication continues to grow, so too does our ability to unlock the secrets of aging. By harnessing the power of communication between cells, we can pave the way for a future where healthy aging is within reach for all.


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